| abstract |
"BENZAMIDE COMPOUNDS AND THEIR USE". The present invention relates to compounds of formula (I) wherein R1 and R2 are each independently lower alkyl, lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto sulfo, hydrogen, nitro, cyano or hydroxy, or may form an annular structure; Q1 is N or CH; L is an optionally substituted unsaturated 3 to 10 membered heterocyclic group; X is monocyclic arylene or monocyclic heteroarylene, each optionally substituted; Y is - (A ^ 1 ^) ~ m ~ ^ - ^ (A ^ 2 ^) ~ n ~ ^ - ^ (A ^ 4 ^) ~ k ~ ^ - ^; Z is direct bond, -CH-2-, -NH- or -O-; and R is hydrogen or lower alkyl, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for the prophylaxis and treatment of diseases or conditions resulting from elevated Apo B circulation levels. |