| abstract |
"COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVAT, PHARMACEUTICAL COMPOSITION, USE OF THE COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVAT, PROCESS OF PROPHYLACY AND INFLAMMATORY DISEASE, PROPULATIC DISEASES, Compounds of formula (I) wherein: R 1 = C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 alkynyl-Y 1 -, aryl-Y ^ 1 ^ -, heteroaryl-Y ^ 1 ^ -, aryl- (O) ~ t -aryl-Y ^ 1 ^ -, aryl- (O) ~ t -heteroaryl-Y ^ 1 ^ -, heteroaryl- (O) ~ t -aryl-Y1-4-, heteroaryl- (O) ~ t -heteroaryl-Y1-4-, C 2-6-alkenyl-Y1-4-, aryl-OY ^ 1 ^ -, heteroaryl-OY ^ 1 ^ -, C 1-6 alkyl-SO-2 ~ -Y ^ 1 ^ -, MY ^ 1 ^ -, J ^ 2 ^ -Y ^ 1 ^ CN or C 3-8 cycloalkyl-Y 1 or C 3-8 cycloalkenyl-Y 1, wherein cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C 1-4 groups. 1-6 alkyl; R2 is hydrogen or C1-6 alkyl; X represents ethylene or a group of the formula wherein R 4 and R 4 and R 4 independently represent hydrogen or C 1-4 -alkyl or R 4 and R 4 and R 4 may form. together with the carbon atom to which they are attached a C 3-8 cycloalkyl group; R 3 and R 4 independently represent hydrogen or C 1-4 alkyl; Z represents a bond, CO, SO ~ 2 ~, CR ^ 9 ^ R ^ 6 ^ (CH ~ 2 ~) ~ n ~, (CH ~ 2 ~) ~ n ~ CR ^ 9 ^ R ^ 6 ^, CHR ^ 6 ^ (CH ~ 2 ~) ~ n ~ O, CHR ^ 6 ^ (CH ~ 2 ~) ~ n ~ S, CHR ^ 6 ^ (CH ~ 2 ~) ~ n ~ OCO, CHR ^ 6 ^ (CH ~ 2 ~) ~ n ~ CO, COCHR ^ 6 ^ (CH ~ 2 ~) ~ n ~ or SO ~ 2 ~ CHR ^ 6 ^ (CH ~ 2 ~) ~ n ~; n represents an integer from 0 to 4; process for preparing same, formulations containing them and their use in therapy for the treatment of inflammatory diseases. |