abstract |
"MALONAMIC ACIDS AND THEIR DERIVATIVES AS THYROID RECEIVER LIGANDS". The present invention relates to novel thyroid receptor ligands, and more particularly to malonic acids and their derivatives of Formula I, which are useful in treating obesity, overweight, hyperlipidemia, glaucoma, heart arrhythmias, skin diseases, thyroid disease, hypothyroidism, thyroid cancer, and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary disease, congestive heart failure, hypercholesteremia, depression, and osteoporosis. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders. |