| abstract |
"SUBSTITUTED AMINO DERIVATIVES REPLACED FROM 3-AMINO-1-PHENYL-1H [1,2,4] TRIAZOLE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM". The present invention relates to compounds of formula (I), in which notably R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ each represent, independently of one another, hydrogen, a halogen atom; ONE (C ~ 1 ~ -C ~ 5 ~) alkyl; a (C ~ 1 ~ C ~ 5 ~) alkoxy; a trifluoromethyl or an S-R group, in which R represents a (C ~ 1 ~ C ~ 5 ~) alkyl; R ~ 4 ~ and R ~ 5 ~ represent (C ~ 1 ~ -C ~ 5 ~) alkyl; an alkynyl of 3 to 5 carbon atoms; a (C ~ 3 ~ -C ~ 5 ~) cycloalkyl or an R ~ a ~ -X- (C ~ 1 ~ -C ~ 2 ~) alkyl group, in which R ~ a ~ represents a (C ~ 1 ~ - C ~ 3 ~) alkyl and X represents O; R ~ 6 ~ represents CHR ~ 7 ~ R ~ 8 ~, in which R ~ 7 ~ represents a phenyl group that can be substituted in position 3, 4 and 5 by one or more radicals Z ', with Z' representing a halogen; a (C ~ 1 ~ -C ~ 5 ~) alkyl; a (C ~ 1 ~ -C ~ 5 ~) alkyl-X- or (C ~ 1 ~ -C ~ 3 ~) alkyl-X- (C ~ 1 ~ C ~ 2 ~) alkyl in which X represents O; or a methylenedioxy group; and R ~ 8 ~ represents (C ~ 1 ~ -C ~ 6 ~) alkyl; (C ~ 3 ~ -C ~ 5 ~) cycloalkyl (C ~ 1 ~ -C ~ 3 ~) alkyl; (C ~ 1 ~ -C ~ 3 ~) alkyl-X (C ~ 1 ~ -C ~ 3 ~) alkyl in which X represents O. These compounds are similar to CRF receptors. |