http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0016980-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9afcdbb9ef9ff258c504f3332f12a427 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-07 |
| filingDate | 2000-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65547b89590f04ceba9fd0c08a582f45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15fd74cd723918a95f5a97c428e6fcea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfbab296723bf3e750f0ec7b63aecac3 |
| publicationDate | 2002-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0016980-A |
| titleOfInvention | A process for the preparation of 6- (2-3, -dichlorophenyl) -1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
| abstract | "A PROCESS FOR THE PREPARATION OF 6- (2,3-DICLOROFENIL) -1,2,4-TRIAZINE-3,5-DIAMINE, COMMONLY KNOWN AS LAMOTRIGIN". characterized by the fact that it comprises a process for the preparation of 6- (2,3-dichloropheni) -1,2,4-triazine-3-5diamine (lamotrigine) of formula I: 2,3-Dichloronitrobenzene in C1-C6 aliphatic alkanol is hydrogenated at a gas pressure of 55-90 psi using metal catalyst at temperatures of 27 <198> -3S <198> C. 2,3-dichloroaniline is diazotized and diazonized from cyan to metal cyanide at temperatures of 65 <198> -80 <198> C. 2,3-Dichlorobenzonitrile is hydrolyzed and 2,3-Dichlorobenzoic acid is chlorinated at temperatures of 55 <198> -130 <198> C. The dehalogenation of the cyan of the 2,3-dichlorobenzoyl chloride is performed with a metal cyanide and alkali metal iodide by refluxing in an aprotic solvent under an inert atmosphere. 2,3-Dichlorobenzoyl cyanide is condensed with aminoguanidine bicarbonate in an organic solvent under acidic conditions using a catalyst at temperatures of 90 <198> -125 <198> C, followed by the unsuitable cyclization of the Schiff base by reflux in an alkanol aliphatic based. The raw lamotrigine is purified. |
| priorityDate | 2000-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.