| abstract |
"PIRROLEUM COMPOUNDS [2,3-D] PYRIMIDINE". A compound of the formula where R ^ 1 ^, R ^ 2 ^ and R ^ 3 ^ are as defined above, which are inhibitors of protein enzyme kinases such as Janus Kinase 3 and, as such, are a useful therapy as immunosuppressive agents in transplants organ, xeno-transplantation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, disease Alzheimer's disease, Leukemia and other autoimmune diseases. |