http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0011997-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 |
| filingDate | 2000-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7db4e7d81d0e4797a0bdac593020c0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea3e159d38afb49456abe190717fa5e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df89ad17efbbbb2caf93ae1dd5fca42a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd310cdbb0530a88e821212d18682b7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e51d1827e9baa3bd4fec45dd7033e764 |
| publicationDate | 2002-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0011997-A |
| titleOfInvention | Respiratory syncytial virus replication inhibitors |
| abstract | Invention Patent: "INHIBITORS OF THE REPLICATION OF THE RESPIRATORY SYNCHIC VIRUS". The present invention relates to compounds of formula (1), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof where -a ^ 1 ^ = a ^ 2 ^ -a ^ 3 ^ = a ^ 4 ^ -represents a divalent radical of the formula -CH = CH-CH = CH-; -N = CH-CH = CH-; -CH = N-CH = CH-; -CH = CH-N = CH-; or -CH = CH-CH = N-; where each hydrogen atom can be optionally substituted; Q is a radical of formulas (bl), (b-2), (b-3), (b-4), (bS), (b-6), (b-7) and (b-8), where Alk is C ~ 1 ~ -C ~ 6 ~ alkanediyl; Y ^ 1 ^ is a divalent radical of the formula -NR ^ 2 ^ - or -CH (NR ^ 2 ^ R ^ 4 ^) -; X ^ 1 ^ is NR ^ 4 ^, S, S (= O), S (= 0) ~ 2 ~, O, CH ~ 2 ~, C (= O), C (= CH ~ 2 ~), CH (OH), CH (CH ~ 3 ~), CH (OCH ~ 3 ~), CH (SCH ~ 3 ~), CH (NR ^ 5a ^ R ^ 5b ^), CH ~ 2 ~ -NR ^ 4 ^ or NR ^ 4 ^ -CH ~ 2 ~; X ^ 2 ^ is a direct bond, CH ~ 2 ~, C (= O), NR ^ 4 ^, C ~ 1 ~ -C ~ 4 ~ alkyl-NR ^ 4 ^, NR ^ 4 ^ - C ~ 1 ~ - C ~ 4 ~ alkyl; t ranges from 2 to 5; u ranges from 1 to 5; v is 2 or 3; and what each hydrogen atom in Aik and (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8) can be optionally replaced by R ^ 3 ^; with the proviso that when R ^ 3 ^ is hydroxy or C ~ 1 ~ - C ~ 6 ~ alkyloxy, then R ^ 3 ^ cannot replace a hydrogen atom at position <244> with respect to a nitrogen atom; G is a direct bond or optionally substituted C ~ 1 ~ - C ~ 10 ~ alkanediyl; R ^ 1 ^ is an optionally substituted bicyclic heterocycle; R ^ 2 ^ is hydrogen, formyl, C ~ 1 ~ - C ~ 6 ~ alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C ~ 3 ~ - C ~ 7 ~ cycloalkyl or C ~ 1 ~ - C ~ 10 ~ substituted alkyl with N (R ^ 6 ^) ~ 2 ~ and optionally with another substituent; R ^ 3 ^ is hydrogen, hydroxy, C ~ 1 ~ - C ~ 6 ~ alkyl, C ~ 1 ~ - C ~ 6 ~ alkyloxy, C ~ 1 ~ - C ~ 6 ~ alkyl or C ~ 1 ~ - C aryl ~ 6 ~ alkyloxy; R ^ 4 ^ is hydrogen, C ~ 1 ~ - C ~ 6 ~ alkyl or C ~ 1 ~ - C ~ 6 ~ alkyl; R ^ 5a ^, R ^ 5b ^, R ^ 5c ^ and R ^ 5d ^ are hydrogen or C ~ 1 ~ - C ~ 6 ~ alkyl; or R ^ 5a ^ and R ^ 5b ^ or R ^ 5c ^ and R ^ 5d ^ taken together form a divalent radical of the formula - (CH ~ 2 ~) ~ s ~ where s is 4 or 5; R ^ 6 ^ is hydrogen, C ~ 1 ~ - C ~ 4 ~ alkyl, formyl, C ~ 1 ~ - C ~ 6 ~ alkyl, C ~ 1 ~ - C ~ 6 ~ alkylcarbonyl or C ~ 1 ~ - C ~ hydroxy 6-alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrizinyl, pyridazinyl; as inhibitors of respiratory syncytial virus replication; their preparation, compositions containing them and their use as a medicine. |
| priorityDate | 1999-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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