| abstract |
Invention Patent: "METHOD OF PRODUCING NITRO-GUANIDINE AND NITROENAMINE DERIVATIVES". Method of producing the compounds of the formula in which R ~ 1 ~ is hydrogen or C ~ 1 ~ -C ~ 4 ~ alkyl; R ~ 2 ~ is hydrogen, C ~ 1 ~ -C ~ 8 ~ alkyl, C ~ 3 ~ -C ~ 6 ~ cycloalkyl or a -N (R ~ 3 ~) R ~ 4 ~ radical; or R ~ 2 ~ and R ~ 6 ~ together are -CH ~ 2 ~ -CH ~ 2 ~ -S-; R ~ 3 ~ and R ~ 4 ~ are hydrogen, C ~ 1 ~ -C ~ 4 ~ alkyl, C ~ 3 ~ -C ~ 6 ~ cycloalkyl or a -CH ~ 2 ~ B radical; R ~ 6 ~ is hydrogen, C ~ 1 ~ -C ~ 8 ~ alkyl, aryl or benzyl; or R ~ 3 ~ and R ~ 6 ~ together are -CH ~ 2 ~ -CH ~ 2 ~ -, -CH ~ 2 ~ -CH ~ 2 ~ -CH ~ 2 ~ -, -CH ~ 2 ~ -O-CH ~ 2 ~ -, -CH ~ 2 ~ -S-CH ~ 2 ~ or -CH ~ 2 ~ -N (R ~ 5 ~) -CH ~ 2 ~ -; X is CH-CN; CH-NO ~ 2 ~ or N-NO ~ 2 ~; A is an optionally substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is phenyl, 3-pyridyl or optionally substituted thiazolyl; characterized by the fact that a compound of the formula in which R ~ 2 ~, R ~ 6 ~ and X have the same meaning as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of the formula in which A and R ~ 1 ~ have the same meaning as given above in formula (I) and Q is a leaving group. |