| abstract |
"PIPERIDINE DERIVATIVES, EPIPERAZINE TETRAHYDROPYRIDINE; COMPOUND; PHARMACEUTICAL COMPOSITION; USE AND METHOD". A piperidine, tetrahydropyridine or piperazine derivative having formula (1), any of its enantiomers or any mixture thereof, or an acid addition salt thereof, where B is C ~ 1-10 ~ alkylene, C ~ 1-10 ~ alkenylene or C ~ 1-10 ~ alkynylene; X is -O-, -S- or -CR ^ 4 ^ R ^ 5 ^ -; and Y is -CR ^ 6 ^ R ^ 7 ^ -, -CR ^ 6 ^ R ^ 7 ^ CR ^ 8 ^ R ^ 9 ^ -, or -CR ^ 6 ^ = CR ^ 7 ^ -; or X and Y together form a group -CR ^ 4 ^ = CR ^ 5 ^ -, or CR ^ 4 ^ = CR ^ 5 ^ -CR ^ 6 ^ R ^ 7 ^ -; Z is -O-, or -S-; W is N, C or CH, and the dotted line is an optional union; A is a bicyclic ring selected from (Ia) or (Ib), where E ^ 1 ^, E ^ 2 ^ and E ^ 3 ^ are selected from O, S, N, NR ^ 11 ^, C, CR ^ 12 ^ e CHR ^ 13 ^, and the dotted line indicates an optional union, provided that E ^ 2 ^ and E ^ 1 ^ and / or E ^ 3 ^ cannot simultaneously be O or S. The compounds of the invention are considered useful for the treatment of affective disorders, such as depression, psychosis, anxiety disorders including general anxiety disorder, panic disorder, obsessive compulsive disorder and eating disorders. |