| abstract |
Invention Patent: "POLYPEPTIDE VARIABLES WITH INCREASED CAPACITY FOR CONNECTION WITH HEPARINE". The invention relates to polypeptide variants with increased heparin binding capacity. The increased binding capacity with heparin is achieved by adding, inserting, and / or replacing an amino acid sequence X ~ 1 ~ X ~ 2X ~ 3 ~ X ~ 4X ~ 5 ~ X ~ 6 ~ (SEQ ID NO.1 OR NO. 2). The polypeptide variants according to the invention are particularly suitable for stimulation of chondrogenesis, osteogenesis, and wound healing. The invention also relates to amino acid molecules which encode said polypeptide variants, host cells containing said nucleic acid molecules, and processes for producing the polypeptide variants. |