| abstract |
Invention Patent: <B> "ACID AMIDAS 7 - [(4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBONYL) AMINO] -QUINOLI NA-3-CARBOXYLIC AND METHODS OF INHIBITION OF THE SECRETATION OF APOLIPOPROTEIN B" <D>. The invention relates to compounds of Formula I that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds and to methods of treatment and / or prevention of atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia, pancreatitis, myocardial infarction, stroke, restenosis or Syndrome X. This invention also relates to methods of reducing the secretion of apolipoprotein B and / or inhibiting the microsomal triglyceride transfer protein. |