http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0002246-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_096a1603c6abd9836906a6226c0cda78 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-30 |
| filingDate | 2000-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb1c527a717ebf559886c4febcb5069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7ba6a4bfb5590aba531be93c6c1f9c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3da3c1995280ceeee8bf042737e316c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c724ac6629b59a8f6157019b970959ae |
| publicationDate | 2003-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0002246-A |
| titleOfInvention | Process for obtaining the enantiomers of racemic bupivacaine, process for obtaining pharmaceutical compositions based on levobupivacaine: pharmaceutical compositions based on levobupivacaine formulated in basic forms or pharmaceutically acceptable salts and use of pharmaceutical compositions based on levobupivacaine formulated in basic forms or pharmaceutically salts acceptable |
| abstract | "Process of obtaining the ENANTIÈMEROS OF racemic bupivacaine, PROCESS compositions of obtaining pharmaceutical BASE levobupivacaine; Pharmaceutical Compositions levobupivacaine BASE MADE IN BASIC OR SALTS FORMS pharmaceutically acceptable AND USAGE OF PHARMACEUTICAL COMPOSITIONS levobupivacaine BASE MADE IN Basic Shapes OR SALTS PHARMACEUTICALLY ACCEPTABLE ". The present invention describes a novel method of separating bupivacaine enantiomers which consists of a continuous cold separation procedure via selective precipitation of its tartaric acid diastereomers. This cold processing avoids the degradation of the reagents giving continuous processing character to the procedure. Another object of the present invention relates to enantiomeric manipulation of bupivacaine enantiomers in order to obtain pharmaceutical compositions having varying enantiomeric excesses of levobupivacaine in order to quantify and determine the participation of dextroisomer in anesthetic and cardiotoxic effects. These enantiomerically engineered compositions have been shown to show significant improvement in anesthetic properties, which have been shown to be similar to racemic bupivacaine, having a cardiotoxic profile similar to that of enantiomerically pure levobupivacaine. |
| priorityDate | 2000-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.