| abstract |
The invention relates to an oral medicinal composition containing a cholinergic agent, in particular a natural plant alkaloid selected from the group of lobeline, anabasine, cytisine, galantamine or their acceptable salts, in the form of tablets and capsules. Excipients of the created oral composition include cellulose powder, calcium sulfate, colloidal silicon dioxide and magnesium stearate, with a total content of cellulose powder and calcium sulfate dihydrate from 64.5 to 97.5%, based on the mass of the dosage form and at least 90% of the alkaloid particles have a size less than or equal to 100 µm. In addition, the oral composition also contains at least one biologically active amino acid selected from: L-carnitine, tryptophan or a combination thereof. The oral composition according to the present invention achieves a uniform distribution of the active substance in its composition, as well as stability of the composition by means of the participating excipients, selected so as to react minimally with the alkaloid participating in them until the formation of qualitative and quantitative related substances permissible for the pharmaceutical composition. The composition according to the present invention is used in the treatment of addictions and addictions to nicotine, tobacco products and alcohol. |