abstract |
The invention relates to a variant neublastin polypeptide suitable for forming a conjugate comprising a variant neublastin polypeptide bound to a polymer containing a polyalkylene glycol moiety. This conjugate has prolonged bioavailability and in preferred embodiments - prolonged biological activity, compared to unmodified wild-type neublastin forms. Conjugates are suitable for therapeutic and non-therapeutic applications, e.g., diagnostic applications. |