| abstract |
The invention relates to pyrazole derivatives of formula @ or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R1 to R4 are as described, and methods for their preparation, to intermediates used in their preparation, to compositions and compositions thereof; to the use of these derivatives. The compounds of the invention bind to the enzyme reverse transcriptase and are modulators thereof, in particular inhibitors. The compounds of the present invention are thus useful in the treatment of a number of disorders, including those that interfere with the inhibition of reverse transcriptase. The disorders of interest include those caused by the immune deficiency virus (HIV) and genetically related retroviruses, such as acquired immune deficiency syndrome (AIDS). |