| abstract |
The invention relates to a pharmaceutical composition comprising melatonin and at least one antihypertensive compound, to a method of treating patients resistant to antihypertensive agents in the absence of melatonin, to a method of reducing night blood pressure in patients with abnormal blood pressure rhythm absence or presence of antihypertensive agents. The invention relates to a method of affecting patients with at least one of these effects, for example, improving mood and daily alertness, delaying the peak value of cortisol, also for the potential prevention and protection against the deleterious effects of ischemia of the heart, wherein melatonin is administered in effective quantities and in an appropriate manner. |