| abstract |
The invention relates to novel 6-alkenyl- and 6-alkynyl-epothilone derivatives of general formula wherein R1a, R1b, R2a, R2b, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G , Y and Z are as defined in the description. The new compounds interact with tubulin by stabilizing the microtubules that are formed. They can affect cell division in a phase-specific manner and find application of a disease or condition related to the need for cell growth, division and / or proliferation. The compounds are suitable for the treatment of malignant tumors such as ovaries, stomach, colon, adenocarcinomas, mammary carcinomas, lung, head and neck cancer, malignant melanoma, acute lymphocytic leukemia and myelocytic leukemia. The compounds are suitable for anti-angiogenesis therapy and for the treatment of chronic inflammatory diseases such as psoriasis and arthritis. The invention also relates to methods for the use and preparation of the compounds. |