| abstract |
The invention relates to an enteric coated pharmaceutical composition comprising a tablet core and having an enteric coating enveloping the core comprising an acid labile drug which is didanosine, binder or excipient, disintegrant and lubricant. The enteric coating comprises a copolymer of methacrylic acid and a plasticizer and imparts protection to the nucleus so that the nucleus is protected in a medium of low pH 3 or lower, being able to release the drug at pH 4.5 or higher, wherein the enteric coating is is obtained by raising the pH of the suspension of the enteric coating with an alkalizing agent below the point at which the enteric integrity copolymer of methacrylic acid may be lost. |