abstract |
The invention relates to platinum medicaments, in particular to an improved method for the preparation of platinum complexes of the general formula @@ in which L, L 'and Y have the meanings given in the description. The method involves a first step 1a) in which [PtA4] 2-reacts with L under appropriate conditions in a first solvent to give [PtA3 (L)] -. In the second step 1b) [PtA3 (L)] - reacts with L 'under appropriate conditions in a second solvent to give cis- [PtA2 (L') (L)]. In cases where Y is halogen or hydroxy, a third step (1c) is carried out in which cis- [PtA2 (L ') (L)] is reacted with H2O2, Y2 or an oxidant-containing halogen to give c, t, c - [PtA2Y2 (L ') (L)]. In the cases where Y is a carboxylate, carbamate or carbonate ester, a fourth step is carried out in which an intermediate, when Y is hydroxy obtained in step 1c), is activated with an aprotic acylating agent. In the case where A is not a halide or is different from the original halide, additional step (s) (1d) is carried out in which the primary halide A from one intermediate obtained in step 1a or 1b, 1c or 1d is converted to different halide or a new leaving group (s), such as monodentate hydroxy, alkoxy, carboxy or bidentate carboxylate, phosphonocarboxylate, diphosphonate or sulfate. |