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filingDate 2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b666f2a0e07443af7cc542eddfd235d
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publicationDate 2005-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BG-64598-B1
titleOfInvention PLATINE COMPLEX, METHOD FOR RECEIVING AND THERAPEUTIC APPLICATION
abstract The invention relates to a platinum complex of formula wherein X is a halogen atom and A represents a primary tricyclic amine containing from 10 to 14 carbon atoms which may be substituted on the tricyclic ring by one or two alkyl groups containing from 1 to 4 carbon atoms, and to a complex of said platinum complex comprising a beta- or gamma-cyclodextrin, which may be substituted by a hydroxyalkyl group containing from 1 to 6 carbon atoms. The invention also relates to a process for the preparation of the complex of formula I in which a solution of an alkali metal salt with aminotrihalogenplatinate (II) is reacted in a polar organic solvent or in water with the corresponding tricyclic amine at a temperature range from 0 to 100 degrees C, and to the method of obtaining the second complex. Both of these complexes can be used alone or as part of a pharmaceutical composition for the treatment of cancer.
priorityDate 1998-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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