| abstract |
The compounds are useful for the prevention and treatment of diseases involving the 5-HT4 and / or H3 receptors, in particular in the central nervous system, gastrointestinal system, organs of the lower urinary tract or cardiovascular system. They have the general formula wherein R1 is a (C1-C4) -alkyl group or (C3-C7) -cycloalkylmethyl, X1 is hydrogen or halogenated or (C1-C4) -alkoxy or OR1 and X1 together are a group of formula -OCH2 -, -0 (CH2) 2-, -0 (CH2) 3-, -0 (CH2) 20 or -0 (CH2) 30-, X2 is a hydrogen atom or an amino group, X3 is a hydrogen or halogen atom and R2 is either hydrogen an atom or (C 1 -C 6) -alkyl group optionally substituted or a phenyl- (C 1 -C 4) -alkyl group optionally substituted in the phenyl ring or a phenyl- (C 2 -C 3) -alkenyl group, or phenoxy- (C2-C4) -alkyl group, or cyclo- (C3-C7) -alkylmethyl group, or 2,3-dihydro-1H- an inden-1-yl or 2,3-dihydro-1H-inden-2-yl group, or a group of the general formula - (CH2) nCO-Z, in which n is 1 to 6 and Z is piperidin-1- silt or 4- (dimethylamino) piperidin-1-yl group. |