| abstract |
The new taxoids exhibit strong antitumor activity. They have the general formula wherein R represents a substituted alkyl or optionally substituted alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl or aromatic 5- or 6-membered heterocyclic radical, Z represents a hydrogen atom or a radical of the general formula wherein R1 optionally substituted benzoyl, thienyl or furyl radical or R 2 -O-CO- wherein R 2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclic radical, R 3 represents alkyl, alkenyl, cic oalkilov, phenyl, naphthyl or aromatic heterocyclic radical. |