http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-62730-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 1997-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e6207a47cc084c3037bfb474bf73167 |
| publicationDate | 2000-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BG-62730-B1 |
| titleOfInvention | CHINASOLINE DERIVATIVES |
| abstract | Quinazoline derivatives may find use as receptor tyrosine kinase inhibitors for the treatment of proliferative diseases, for example, cancer. They have the formula in which n is 1, 2 or 3, and each R2, independently of one another, is halogen, trifluoromethyl or (C1-4) alkyl, R3 is (C1-4) alkoxy and R1 is di [(C1-) 4) alkyl] amino- (C2-4) alkoxy, pyrrolidin-1-yl- (C2-4) alkoxy, piperidino- (C2-4) alkoxy, morpholino- (C2-4) alkoxy, piperazin-1-yl- (C2-4) alkoxy, 4- (C1-4) alkylpiperazin-1-yl- (C2-4) alkoxy, imidazol-1-yl- (C2-4) alkoxy, di - [(C1-4) alkoxy- (C2-4) alkyl] amino- (C2-4) alkoxy, thiamorpholino- (C2-4) alkoxy, 1-oxothiamorpholino- (C2-4) alkoxy or 1,1-dioxothiamorpholino- (C2-4) alkoxy. Each of the R 1 substituents containing a methylene group which is not attached to an N or O atom optionally bears a hydroxy substituent thereon. The invention also relates to a pharmaceutically acceptable salt of said compounds, a process for their preparation, pharmaceutical compositions containing them, and administration thereof. |
| priorityDate | 1995-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 316.