http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-62694-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6a8b2ba2fc0db9637e07892982a2512 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-02 |
| filingDate | 1997-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_381524747988acfe5522f1c5d039c81c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58baa587a21a5997fa82360cfa24b41c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_127b54d1ae4a9a4636d0932b29bacac8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3258f3be9b8a0d1a15f20513d965059b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fed68e66889fc3326fbf37db40dac496 |
| publicationDate | 2000-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BG-62694-B1 |
| titleOfInvention | METHOD FOR PREPARING 2-DIETYLAMINOETHYLCHLOROHYDROCHLORIDE |
| abstract | The compound 2-diethylaminoethylchloride hydrochloride (DEAEXXX) is used in the pharmaceutical industry, in particular for the preparation of isothioronium salt, 2-diethylaminoethanethiol and diethylaminoethanethiol hydrochloride. The method for its preparation involves reacting 2-diethylaminoethanol with thionyl chloride in an organic solvent in high yield and purity. To a solution of thionyl chloride in chloroform was added 2-diethylaminoethanol at a temperature of 30 to 400 ° C for 1-2 hours, further stirred for 1-2 hours at this temperature, and then the temperature was raised to 65-700 ° C to separate the resulting dioxide. The chloroform and unreacted thionyl chloride are then removed and returned to the next synthesis as the chloroform. The reaction mass is subjected to recrystallization of DEAEEXX by adding ethyl or methyl alcohol or another organic solvent which dissolves impurities contaminating the product. The resulting DEAEXXX crystals are filtered and dried and the filtrate is distilled to remove the ethyl alcohol and recrystallized with ethyl alcohol and diethyl ether or returned to the next cycle of the DEAEECHX recrystallization step. The purity of the product is 97-98.6% and the yield is 94-96. |
| priorityDate | 1997-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.