| abstract |
The compounds stimulate the peristalsis of the gastrointestinal tract. They have the formula wherein a is a radical of formula -CH2-CH2-, -CH2-CH2-CH2 or -CH2-CH2-CH2-CH2-, wherein one or two hydrogen atoms in these radicals may be substituted by a C1-6 alkyl radical; r 1 is halo, r 2 is hydrogen, amino, monoyl or di (C 1-6 alkyl) amino or C 1-6 alkylcarbonylamino; r 3 is hydrogen or C 1-6 alkyl; l is c 3-6 cycloalkyl, c 5-6 cycloalkanone, c 3-6 alkenyl optionally substituted with aryl, or l is a radical of formula -aik-r4, -aik-x-r5, -aik-y-c (= O) -r7 or - aik-y-c (= 0) -nr9r10. The invention also relates to their n-oxide forms, to their addition salts and to their stereochemically isomeric forms, to pharmaceutical compositions comprising as active ingredient these compounds, and also to a process for their preparation. |