abstract |
The invention relates to a process for the preparation of citalopram and its pharmaceutically acceptable salts. By the method of 1- [3- (dimethylamino) -propyl] -1- (4-fluorophenyl) -1,3-dihydro-5-isobenzofurancarbaldoxime, O-substituted, preferably with a diphenylmethyl or triphenylmethyl group, is treated with formicacetic anhydride. The invention also relates to the complete synthesis of citalopram as a free base or in the form of a pharmaceutically acceptable salt thereof, starting from 5-formylphthalide by the scheme. a |