| abstract |
The invention relates to compounds of the general formula wherein R 1 is selected from the group consisting of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine-N-oxide; R 2 is independently selected from ethyl and isopropyl; R 3 is independently selected from hydrogen and fluoro; R4 is independently selected from -OH, -NH2 and -NHSO2R5; and R 5 is independently selected from hydrogen, -CF 3 and C 1 -C 6 alkyl, or their salts or individual enantiomers and their salts, each R 1 heteroaromatic ring optionally and independently optionally substituted by 1, 2 or 3 substituents selected from linear and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo and iodo. The substitutions on the phenyl and heteroaromatic rings can be carried out at any position of the ring systems. The invention also relates to their pharmaceutically acceptable salts and pharmaceutical compositions containing the new compounds and to their use in medicine, in particular for the treatment of pain, depression and functional gastrointestinal disorders. a |