| abstract |
The invention relates to compounds of the general formula wherein R 1 is selected from phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl and pyridine-N-oxide, where each R 1 phenyl ring and R 1 heteroaromatic ring can be optionally and independently additionally substituted with 1, 2 or 3 substituents selected independently from linear and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo and iodo. Substitutions of the phenyl and heteroaromatic rings can be carried out at any position of the ring systems. The invention also relates to their pharmaceutically acceptable salts and pharmaceutical compositions containing the novel compounds and to their use in therapy, in particular for the treatment of pain, depression and functional gastrointestinal disorders. a |