| abstract |
This invention is directed to aromatic sulfone hydroxamates and salts thereof that inhibit matrix metalloproteinase activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase effective amount to an animal, particularly a mammal having a pathological condition associated with MMP and/or aggrecanase activity. 405 claims |