| abstract |
The present invention relates to novel imidazolidine derivatives of formula in which A, E, Z, R1, R2, R3, R4 and R5 have the meanings indicated in the description. The compounds of formula (I) are valuable pharmaceutical active compounds, which are suitable, for example, for the treatment of inflammatory diseases, for example of rheumatoid arthritis, or of allergic diseases. The compounds of the formula (I) are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the treatment of diseases which are caused by an undesired extent of leukocyte adhesion, and/or leukocyte migration or are assosiated therewith or in which cell-cell or cell-matrix interactions which are based on the interactions of VLA-4 receptors with their ligands play a role. The invention furthermore relates to processes for the preparation of the compounds of formula (I), their use and pharmaceutical preparations which contain compounds of formula (I). 16 claims |