| abstract |
The invention relates to beta-3 adrenergic receptor agonists of the structural formula wherein Ar is pyridyl, oxazolyl, thiazolyl or phenyl; R5 is a 5- or 6-membered heterocycle; X is a direct bond or oxygen and Y is a direct bond, alkylene, OCH2, CH2O or oxygen. The invention relates to their stereoisomers and prodrugs, to the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, as well as to intermediates used to prepare the compounds of the formula I and combinations thereof, to their stereoisomers and prodrugs and to pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs. |