| abstract |
The invention relates to a process for the production of molded bodies by injection molding, which is carried out in three stages. In the first step, a (meth) acrylate copolymer consisting of 85 to 98% by weight is melted and mixed. radically polymerized C1 to C4-alkyl esters of acrylic or methacrylic acid of from 15 to 20% by weight. (meth) acrylate monomers having one quaternary ammonium group in the alkyl radical, from 10 to 25% by weight. softener, as well as from 10 to 50% by weight. siccative and / or 0.1 to 3% by weight. a lubricant release agent and, optionally, other conventional pharmaceutical additives or adjuvants and / or a pharmaceutically active substance. During the second step, the mixture is degassed at a temperature of at least 1200 ° C, wherein the content of low boiling components with a partial pressure of at least 1.9 bar at 1200C decreases to at least 0.5% by weight. The third step involves casting the degassed mixture at a temperature of 80 to 160 ° C in the mold of a die casting apparatus and separating the molded body from the mold. |