| abstract |
The invention relates to granules with a controlled rate of effervescence. In some embodiments, the granules include an acidic agent, an alkaline agent, a pharmacologically active agent, a hot-extrudable binder capable of forming a eutectic mixture with the acidic agent, and optionally a plasticizer. The effervescent granules are obtained by the hot extrusion method. The invention also relates to a method comprising heating. The granules may contain pharmacologically active agents such as drugs, antidiarrheal agents, antiviral agents, anxiolytic agents, cholesterol-lowering agents, alpha adrenergic blocking agent, phenanthrene derivative. The drugs may be phenanthrene derivatives, such as morphine sulfate, and a morphine derivative, such as hydromorphone hydrochloride. |