| abstract |
The invention relates to novel substituted 4- (phenyl-N-alkyl) -piperazine and 4- (phenyl-N-alkyl) -piperidine Compounds of formula (N) wherein X is N, CH and C, where X can only be C, where the junction includes a double bond in place of the dashed line; R1 is CF3, OSO2CF3, OSO2CH3, SOR7, SO2R7, COR7, CN, OR3NO2 and CONHR3, 3-thiophene, 2-thiophene, 3-furan, 2-furan, F, Cl, Br, I, R2 and F, Cl. Br, I, CN, CF3, CH3, OCH3, OH and NH2, R3 and R4, independently of one another, denote H or C1-C4 alkyl, R5 - C1-C4 alkyl, allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-Trifluoropropyl, 4,4,4-trifluorobutyl or - (CH2) -R6, R6 - C3-C6 cycloalkyl, 2-tetrahydrofuran or 3-tetrahydrofuran, R7 - C1-C3 alkyl, CF3 or N (R4) 2. The invention also relates to the pharmaceutically acceptable salts of said compounds, to the pharmaceutical compositions containing them, and to methods of using them for the treatment of diseases of the central nervous system. |