| abstract |
The compounds exhibit angiogenesis inhibiting activity. They have the formula wherein the ring comprising A, B, D, E and L is a phenyl or nitrogen-containing heterocycle; groups X and Y may be any one of a plurality of defined linker units; R1 and R2 may be independently substituted or together may be a ring-forming bridge; the ring J may be an aryl, pyridyl or cycloalkyl group; and the G-groups may be any of a plurality of defined substituents. The invention also relates to pharmaceutical compositions containing said compounds and to methods of treating conditions characterized by irregular angiogenesis or processes associated with hyper permeability using said compounds. |