http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-106522-A

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filingDate 2002-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_177f2d8692d5fce8eb7c8b2913f673ef
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publicationDate 2003-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BG-106522-A
titleOfInvention A METHOD FOR OBTAINING AN ALMAMINE DISSOLVED DERIVATIVES AND THEIR RELEVANT SALTS
abstract The invention relates to a process for the preparation of (E) -N-methyl-N- (1-naphthylmethyl) -6,6-dimethylhept-2-en-4ynyl-1-amine of the formula I, of its corresponding acid salts. By the process, the chloro compound of the formula IIIb described in the description containing the E and Z isomers in the ratio of 3.3-3.4: 1 and obtained by the reaction of the secondary alcohol of formula IV of the description with hydrochloric acid reacts with the secondary amine of formula II from the description in a solvent-type aliphatic ketone in the presence of a base and, if desired, a iodide salt catalyst. Then, the compound of formula I obtained in basic form and isomer ratio of 3.3-3.4: 1 is converted directly into the hydrochloric acid salt with hydrochloric acid, the precipitated hydrochloride of the E-isomer is removed, if desired, the base is liberated and is converted to a pharmaceutically acceptable acid salt by a known method. The resulting product is an active agent of a known antifungal drug.
priorityDate 2002-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 26.