abstract |
The invention relates to the use of a compound of the formula or a salt, ester, amide or prodrug thereof in which X is O or S, S (O) or S (O) 2, NH or NR12 wherein R12 is hydrogen or C1 -Alkyl; (O) R9, S O) 2 OR 9, C (O) NR 10 R 11, S (O) NR 10 R 11, S (O) OR 10 R 11, wherein R 9, R 10 or R 11 are different specific organic groups; R6 is hydrogen, optionally substituted hydrocarbyl or optionally substituted heterocyclyl; R7 and R8 are different organic specific groups; R 1, R 2, R 3, R 4 are independently selected from halo, cyano, nitro, C 1-3 alkylsulfanyl, -N (OH) R 13-, wherein R 7 is hydrogen or C 1-3 alkyl or R 15 X 1- wherein X 1 represents a direct bond, -O-, -CH2-, -OCO-, carbonyl, -S-, -SO-, -SO2-, -NR16CO-, -CONR16-, -SO2NR16-, -NR17SO2- or -NR18-, wherein R16, R17 and R18 are each independently hydrogen, C1-3 alkyl or C1-3 alkoxyC2-3 alkyl, and R9 is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy. The compounds are used in the preparation of a medicament useful for inhibiting aurora 2 kinase. |