| abstract |
The invention relates to tricyclic compounds of the formula wherein R 1 is hydrogen or hydroxy, R 2 is hydrogen or hydroxy; R1 and R2 together are oxygen; A is a bond, CH 2, CHCH 3, CH 2 CH 2 or C (CH 3) 2; R 3 and R 4 are the same or different and are hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 4 alkoxy, trifluoromethyl, NO 2, COR 6, COOR 6 or NR 6 R 7 wherein R 6 and R 7 are the same or different and are hydrogen, C 1 -C 6 alkyl or benzyl ; R 5 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, (O = C 1 -C 6 alkyl), (O = C 2 -C 6) alkenyl, (O = cycloalkyl wherein said alkyl, alkenyl and cycloalkyl groups may be substituted with 1, 2 or 3 groups selected from the group consisting of halo, C 3 -C 6 cycloalkyl, phenyl or substituted phenyl, and to their salts. The compounds are used to treat neuropathic and other CNS diseases. |