| abstract |
The invention relates to compounds of the formula wherein R 1 -R 5 are independently selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms 3 to 10-membered heterocycloalkyl, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8 , -NR 6 N (R 7 R 8), -N (R 7 R 8) or WY - (CH 2) n Z, provided that at least one of R 1 -R 5 is not hydrogen; or R 2 and R 3 or R 3 and R 4 taken together form 3- to 7-membered heterocycloalkyl or 3- to 7-membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3- to 10-membered heterocycloalkyl, aryl, heteroaryl, or R7 and R8 taken together form 3- to 7-membered heterocycloalkyl; R 9 -R 12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms or cyano or R 9 and R 10 or R 11 and R 12 may together form aryls 5 to 7 carbon atoms; provided that at least one of R9-12 is not hydrogen; W is O, NR6 or absent, Y is - (CO) - or - (CO2) -, or absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, -COR6, -CONR7R8, -OCOR6, NR6COR7, -OCONR6-OR6, -SR6, -SOR6, -SO2R6, SR6N (R7R8) or phenyl; G is aryl or fused bulls |