| abstract |
The invention relates to compounds of formula to their N -oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof. In the formula Alk is C1-6alkanediyl; n has a value of 1 or 2; X1 is -O-, -S-, -S (= O) - or -S (= O) 2-; each R 1 is independently hydrogen, halogen, C 1-6 -alkyl, nitro, hydroxy or C 1-4 -alkyloxy; D is an optionally substituted mono-, bi- or tricyclic nitrogen containing heterocycle, 2H-benzopyranone, benzamide, benzophenone or phenoxyphenyl. Said compounds exhibit central alpha2-adrenoceptor antagonist activity. The invention also relates to their preparation, to their pharmaceutical use and to compositions containing them. |