| abstract |
The invention relates to novel substituted indolinones of the general formula wherein X and R1 to R5 are as defined in the description to their salts and isomers with useful pharmacological properties. Compounds of general formula I wherein R1 represents a hydrogen atom, a C1-3 alkyl group or a prodrug radical have useful pharmacological properties, in particular an inhibitory action on various kinases, on viral cyclin and on receptor tyrosine kinases. The compounds of general formula (I), in which R1n represents a hydrogen atom, a C1-3 alkyl group or a prodrug radical, are useful intermediates for the preparation of the above mentioned compounds. |