| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dd44111f0182571012bec2b396e841a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47c435dc1691fae44decd66647d5a334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0176eee0e97a6a6e157f3de12c1d1879 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate |
2000-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8db1bfd724370601050c0ff36d9c662e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67e555cd633e754a1fa29e00ffbce70b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fbcb027b6fc3dc03a72010a6f4ad3db |
| publicationDate |
2002-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BG-104937-A |
| titleOfInvention |
METHOD FOR OBTAINING (-) - GALANTAMINE HYDROBROMIDE |
| abstract |
The invention relates to a process for the preparation of (-) - galanthamine, wherein the diphenol derivatives are oxidized with phenyljodoside (III) bis (trifluoroacetate) in a polar solvent at a temperature of 0 to -450C for 10 to 60 minutes. The resulting naphthalene derivative is protected with ethylene glycol and the resulting ketal intermediate is transformed into (R) -ravvedine in high yield by reduction with LiAlH4. Complete conversion of racemic narwein into (-) - narvedine is performed by using (-) - narwein crystals. The resulting (-) - narwedine is reduced stereospecifically to (-) - galanthamine using L-selectivity and subsequent hydrobromic acid treatment produces the hydrobromide salt of (-) - galantamine. |
| priorityDate |
2000-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |