| abstract |
The invention relates to a compound, a solvate thereof of the formula wherein Ar represents an optionally substituted aryl or a C 5-7 cycloalkadienyl group or a C 5-7 cycloalkyl group or an optionally substituted single or fused aromatic heterocyclic group; R represents C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylalkyl, optionally substituted phenyllyl-phenyl-C 1-6 alkyl, optionally substituted hepta heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy-C 1-6 alkyl , amino-C1-6 alkyl, C1-6 alkylamino, di-C1-6 alkylamino, C1-6 acylaminoalkyl, C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6 alkoxycarbonyl, C1-6 alkoxycarbonyl C1-6 alkyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di-C1-6 alkylaminocarbonyl, halo-C1-6 alkyl, or R represents the group - (CH2) p-, wherein p is 2 or 3, First ring with a carbon atom of Ar; R1 represents hydrogen to four possible substituents selected from C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulfonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido , amino or mono- and di-C 1-6 alkylamino; R2 represents the moiety - (CH2) n-NY1Y2 wherein n is an integer from 1 to 9 and Y1 and Y2 are independently selected from hydrogen; C1-6 alkyl; C1-6 alkyl substituted with hydroxy, C1-6 alkylamino or bis- (C1-6 alkyl) amino; C1-6 alkenyl; aryl or aryl-C 1-6 -alkyl or Y 1 and Y 2 together with the nitrogen atom to which they are attached represent an optionally substituted |