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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
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filingDate 1999-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53adc9d9b2221ff3d129b009616d1bb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a84f6eb44fcc6493732c2dad9019df
publicationDate 2000-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BG-103852-A
titleOfInvention COS-2 SELECTIVE CARPROPHENE FOR TREATMENT OF DISEASE AND INFLUENCE IN DOGS
abstract The invention relates to the treatment or prophylaxis of inflammatory processes and diseases in dogs associated with the activity of induced cyclooxygenase-2 (CGG-2). Reduced or eliminable side effects caused by the simultaneous inhibition of the activity of the constitutive cyclooxygenase-1 (CGG-1) by selective inhibition of the CGG-2 activity with respect to CGG-1 activity are reduced or eliminated. The ratio of selectivity or CGG-2: CGG-1 inhibition activity is at least 3: 1 based on ex vivo inhibition levels measured in whole blood. The inhibitor is selected from the group of anti-inflammatory compounds consisting essentially of salicylic acid derivatives, paramiphenol, indole and indene acetic acids, heteroarylacetic acids, arylpropionic acids, anthranilic acids, enolic acids and alkanones. The inhibitor particularly consists of (+) (S) -enantiomeric 6-chloro-methyl-9H-carbazole-2-acetic acid.
priorityDate 1997-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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