| abstract |
The pyrimido [5,4-d] pyrimidines exhibit valuable pharmacological properties, in particular suppressing signal transduction by tyrosine kinases. They are of the general formula in which the meanings of A2, A4, A6 and A8 are as defined in claim 1 in the description. The invention also relates to tautomers, stereoisomers and salts of said compounds, in particular their physiologically acceptable salts with inorganic or organic acids or bases, and their use in the treatment of diseases, in particular tumors, and to their preparation. |