| abstract |
The invention relates to sulfonamides which are inhibitors of matrix metalloproteinases, in particular stromelysin-1 and gelatinase A (72 kD gelatinase). The invention also relates to methods utilizing the compounds for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aaaurea of the artery, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubitus and chronic ulcers or wounds, cancer metastases, tumor angiogenesis, arthritis and other autoimmune or inflammatory disorders dependent on invasion of leukocytes into the tissue. |