http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-101649-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07G11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 |
| filingDate | 1997-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f7f495875d5a6405a6647167b8a2163 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4540cdb3919f7e19aaac4d6960138580 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37822c60d9181d5d54c1e9f9add28b92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed4d62b11073f12e8d732838677591db |
| publicationDate | 1999-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BG-101649-A |
| titleOfInvention | CONTRACTS OF ANTRACYCLINE ANTIBIOTICS, METHOD OF LOADING AND APPLICATION AS ANTI-TUMOR |
| abstract | The invention relates to analogs of anthracycline antibiotics covalently attached to the chitosan biopolymer, as well as methods for their preparation. Conjugates find use as an anti-tumor agent with an extended therapeutic range. They are prepared from pre-oxidized chitosan, the biopolymer being oxidized with periodic acid (0.025-0.25 M), at a pH of 3.5-5.5, in a light-shielded vessel, with continuous stirring for 1 to 6 h. Oxidized chitosan is treated in two ways, producing two types of conjugates. According to Method A, the oxidized chitosan is treated sequentially with urea at a concentration of 10 to 15% and 0.9% sulfuric acid at 650 ° C for 10 to 16 hours, 12% formaldehyde for 3 to 6 hours at a temperature of 30 to 500 ° C and is reacted with the anthracycline antibiotic at a concentration of 1% at a pH of 7.8 for 12 hours, at room temperature and constant stirring. By Procedure B, the oxidized chitosan reacts with the antibiotic in dioxane / water (1: 1) in the presence of a reducing agent, sodium borohydride. Between anthracycline antibiotics (carminomycin, daunorubicin, epirubicin and idarubicin) and chitosan, a covalent bond is created using low temperatures and affordable, inexpensive and non-toxic reagents. The pH range of binding is broad and allows the antibiotic to be immobilized at appropriate pH values preserving its biological activity. In the conjugates obtained, it is possible to interact |
| priorityDate | 1997-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.