| abstract |
The analogs of human -1-anti-chymotrypsin, wherein the amino acid at the 358 position is selected from the group consisting of methionine, isoleucine, valine, alanine, aspartic acid, threonine and glutamic acid, are effective inhibitors of human neutrophil elastase. The invention also relates to nucleic acid sequences encoding the analogs, to expression vectors, to transformed host cells and to a method for producing the analogs. |