http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-100816-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad3d51747a2eba1e7636894263252df4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-886 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D503-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D503-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D503-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-00 |
| filingDate | 1996-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa92ce67572a3fe2559d905aee81726 |
| publicationDate | 1997-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BG-100816-A |
| titleOfInvention | NEW METHOD FOR Isolation of clavulanic acid and frosty pharmaceutically acceptable salts from the fermentation nutrient medium of STRERTOMYCES SR. P 6621 FERM P 2804 |
| abstract | The invention relates to an improved method of isolating clavulanic acid and its pharmaceutically acceptable salts such as potassium clavulanate from a water-soluble fermentation broth of Streptomyces sp. P 6621 FERM P 2804. From the micellar fermentation broth, the major part of the proteins and other suspended solids were separated by microfiltration at a pH of medium of 5.8-6.2 and a temperature of 20 to 40 ° C. The purified nutrient medium (aqueous phase) is optionally further purified by ultrafiltration, then concentrated by reverse osmosis and directly extracted in countercurrent in centrifuge extractors with a water-soluble organic solvent at a pH of medium 1-3. The remaining proteins are simultaneously separated from the resulting organic phase of water-soluble undesirable impurities separated by washing the organic phase water. Thereafter, the organic phase is dried under vacuum in a rectification column to a water content of less than 0.1% v / v, concentrated by evaporation, and decolorized by treatment with activated charcoal. The clavulanic acid present in the dry organic phase, preferably in ethyl acetate, is isolated and purified by reaction with N, N'-diisopropylethylenediamine at room temperature to the intermediate N, N'-diisopropylethylenediammonium diclavulanate. The resulting compound is isolated and then reacted with potassium 2-ethyl hexanoate in isopropanol to give potassium salt of clavulanic acid |
| priorityDate | 1994-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.