| abstract |
The invention relates to compounds of the formula wherein r 1 represents hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, cf 3, nо 2, cn, sra, sora, s02a, s02a, saturyl, C2-6alkenyl, C2-6alkynyl or C1-4alkyl , substituted with C 1-4 alkoxy, wherein r a and r b are each hydrogen or C 1-4 alkyl; R 2 is hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy substituted with C 1-4 alkoxy or C 1-6 alkoxy; R 3 is hydrogen, halogen or CF 3; r4 has the meanings given for r1; r5 is selected from the definitions given for r2; R6 is a 5- or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by = O, = s or a C1-4 alkyl group and optionally substituted by an aminoalkyl group; r9a and r9b are hydrogen or C1-4alkyl, or r9a and r9b are linked so as to form a 5-7 ring; x is a C 1-4 alkylene chain optionally substituted with oxygen and y is a C 1-4 alkyl group optionally substituted with a hydroxyl group, with the proviso that when y is C 1-4 alkyl, R 6 is substituted with at least one aminoalkyl group and to their pharmaceutically acceptable salts and prodrugs. The compounds are useful for the treatment of pain, inflammation, migraine, and emesis. |